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薛璐璐博士，必赢766net手机版/附属鼓楼医院准聘副教授、研究员、至诚青年教授，博士生导师。获国家高层次青年项目（海外）资助（2024）。2020年于德国萨尔大学获得博士学位，2021年-2024年在美国宾夕法尼亚大学（UPenn）生物工程系进行博士后研究（合作导师：Michael J. Mitchell)。2024年12月加入顾宁院士领导的工程医学（Engineering Medicine) 研究组。聚焦于多尺度核酸药物器官特异性递送与转化，围绕基于微纳生物材料、mRNA药物递送技术和基因/免疫治疗开展生物医学工程方向的研究。以第一（含共同第一）和通讯作者在Nature Nanotechnology, Nature Reviews Materials, Nature Materials, Nature Communications, Science Translational Medicine, JACS, PNAS等领域内主流期刊发表论文多篇，被美国生物材料学会（Society for Biomaterials)授予BWF Biointerfaces Rising Award（2024），并受邀在BioInterfaces SIG session上作特邀报告（keynote speaker）。申请专利9项，包括PCT国际专利3项，并授权给生物科技公司做转化研究。

长期招聘博士后和科研助理，热忱欢迎对生物材料、纳米药物、基因治疗等感兴趣的学生前来攻读硕士、博士学位或进行短长期学术交流。期待具有药学、化学、材料、生物、医学等研究兴趣和背景的青年才俊加入！

联系邮箱：lulxue@nju.edu.cn

Expoloration、The Innovation Medicine青年编委

Discover Chemistry客座编辑

Science Advances、Nature Communications、Journal of the American Chemical Society、Angewandte Chemie International Edition、ACS Nano、Bioactive Materials、Journal of Nanotechnology、Journal of Controlled Release等期刊独立审稿人

1. L. Xue^#, A. Thatte^#, D. Mai, R. Haley, N. Gong, X. Han, N. Sheppard, C. June and M. Mitchell. Responsive Biomaterials: Optimizing Control of Cancer Immunotherapy. Nat. Rev. Mater., 2023, 9, 100 (^#: Contributed equally).

2. L. Xue^#, G. Zhao^#, N. Gong^#, X. Han, S. Shepherd, X. Xiong, J. Xu, K. Swingle, C. Warzecha, R. El-Mayta, J. Xu, J. Cui, Y. Shi, M. Alameh, K. Wang, L. Wang, D. Pochan, D. Weissman, A. Vaughan, J. Wilson and M. Mitchell. Combinatorial Design of Siloxane Incorporated Lipid Nanoparticles Augment Tntracellular Processing for Tissue-Specific mRNA Therapeutic Delivery. Nat. Nanotechol., 2025, 20, 132 (^#: Contributed equally).

3. L. Xue, K. Swingle, and M. Mitchell. Small Structural Changes in Siloxane-Based Lipidoids Improve Tissue-Specific mRNA Delivery. Nat. Nanotechnol., 2025, 20, 12.

4. L. Xue, A. Hamiton, G. Zhao, R. El-Mayta, X. Han, N. Gong, X. Xiong, J. Xu, C. Figueroa-Espada, S. Shepherd, A. Mukalel, M. Alameh, J. Cui, K. Wang, A. Vaughan, D. Weissman and M. Mitchell. High-Throughput Barcoding of Nanoparticles Identifies Cationic, Degradable Lipid-Like Materials for mRNA Delivery to the Lungs in Female Preclinical Models. Nat. Commun., 2024, 15, 1884.

5. L. Xue, X. Xiong, G. Zhao, W. Molina-Arocho, R. Palanki, Z. Xiao, X. Han, I. Yoon, C. Figueroa-Espada, J. Xu, N. Gong, Q. Shi, Q. Chen, M. Alameh, A. Vaughan, M. Haldar, K. Wang, D. Weissman and M. Mitchell. Multiarm-Assisted Design of Dendron-Like Degradable Ionizable Lipids Facilitate Systemic mRNA Delivery to the Spleen. J. Am. Chem. Soc., 2025, 147, 1542.

6. L. Xue^#, N. Gong^#, S. Shepherd, X. Xiong, X. Liao, X. Han, G. Zhao, C. Song, X. Huang, H. Zhang, M. Padilla, J. Qin, Y. Shi, M. Alameh, D. Pochan, K. Wang, F. Long, D. Weissman and M. Mitchell. Rational Design of Bisphosphate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment. J. Am. Chem. Soc., 2022, 144, 9926-9937 (^#: Contributed equally).

7. L. Xue, X. Xiong, B. Krishnan, F. Puza, S. Wang, Y. Zheng and J. Cui. Light-Regulated Growth from Dynamic Swollen Substrates for Making Rough Surfaces. Nat. Commun., 2020, 11, 963.

8. N. Gong^#, X. Han^#, L. Xue^#, R. EI-Mayta, A. Metzloff, M. Billingsley, A. Hamilton and M. Mitchell. In Situ PEGylation of CAR T Cells Alleviates Cytokine Release Syndrome and Neurotoxicity. Nat. Mater., 2023, 22, 1571 (#: Contributed equally).

9. G. Zhao^#, L. Xue^#, A. Weiner, N. Gong, S. Adams-Tzivelekidis, J. Wong, M. Gentile, A. Nottingham, M. Basil, S. Lin, T. Niethamer, J. Diamond, C. Bermudez, E. Cantu, X. Han, Y. Cao, M. Alameh, D. Weissman, E. Morrisey, M. Mitchell and A. Vaughan. TGFβR2 Signaling Coordinates Pulmonary Vascular Repair After Viral Injury. Sci. Transl. Med., 2024, 16, eadg6229 (#: Contributed equally).

10. G. Zhao^#, L. Xue^#, H. Geisler, J. Xu, X. Li, M. Mitchell and A. Vaughan. Precision Treatment of Viral Pneumonia through Macrophage-Targeted Lipid Nanoparticle Delivery. Proc. Natl. Acad. Sci. U.S.A. (PNAS), 2024, 121, e2314747121 (#: Contributed equally).

主持国家级青年人才项目（海外）2025-2027

BWF BioInterface Rising Star Award （2024），美国生物材料学会